Image for  Rutin (CHO)
Rutin (C27H30O16)

Synonyms/Common Names/Related Substances:

  • 10163-13-0, 1340-08-5, 2- [3, 4-bis (2-hydroxyethoxy) phenyl]- 3 [[6 - O - (6 - deoxy-alpha-L-mannopyranosyl )-beta-D-glucopyranosyl]oxy] -5-hydroxy-7- (2-hydroxyethoxy) -4H-1-benzopyran-4-one, 3,3',4',5,7-pentahydroxy, 3,3',4',5,7-pentahydroxyflavone-3-rutinoside, 3-(beta-hydroxyethyl)-rutoside, 3-rhamnoglucosylquercetin, 3-rhamnoglycosylquercetin, 3-rutinosyl quercetin, 7, 3', 4'-tris [O- (2-hydroxyethyl)]rutin, alpha-glycosylrutin, ascorutin, benzopyrone, Birutan Forte, buckwheat (Fagopyrum esculentum), dihydroxyethylrutoside, eldrin, Ercevit fort, ergot compound, essaven, flavanoid, flavone-3-rutinoside, Fleboside, Globulariacitrin, Globularicitrin, glucopyranoside, HR, hydrolytic enzymes (HE), hydroxyethyl rutoside, hydroxyethylrutosiden, ilixanthin, melin, myrticalorin, myrticolorin, myticolorin, mono-3'- O-(beta-hydroxyethyl)-rutoside, mono-4'-O-(beta-hydroxyethyl)-rutoside, monohydroxyethylrutoside, NISTC153184, NSC408168, O-(beta-hydroxyethyl)-rutosides, osyritin, osyritrin, oxyritin, oxerutin, paliuroside, Paroven® (UK, S. Africa, Australasia), paveron 75, phlebolan-spray, phlebotropic drugs, phytomelin, Q1, quercetin, quercetin-3-beta-D-rutinoside, quercetin-3-O-beta-rutinoside, quercetin-3-O-rutinoside, quercetin rutinoside, Relvene® (France), rexiluven (DRA 363, Sandoven), ritmilen, rutabion, rutin trihydrate, rutinic acid, rutinion acid, rutosid, rutoside, rutozyd, sandoven, sophorin, tanrutin, tetrahydroxyethyl-quercitin, tetrahydroxyethylrutoside, tri-7,3',4'-hydroxyethylrutoside (tri-HR), tri-(hyroxyethyl)-rutin, trihydroxyethylrutoside ("varemoid"), trioxyethylrutin, troxerutin (CAS 7085-55-4), trypsin, Venoruton® (most of Continental Europe), Venoruton 1000®, Venoruton Forte®, vicalin, violaquercitrin, vitamin P.
  • Selected combination products: Enzyme-rutoside combination (ERC) (rutoside, bromelain and trypsin); Phlebolan® (dimethylsulfoxide and other ingredients) (1); Phlogenzym® (bromelain, trypsin and rutosid trihydrate); Sandovene® (rutin, esculine and dihydroergocristine); SB-LOT (coumarin and troxerutin); Seniosan® (rutin and other ingredients); Venalot® (coumarin and troxerutin); Venalot Depot® (coumarin and troxerutine); Wobenzym® (pancreatin, papain, bromelain, trypsin, chymotrypsin and rutosid).

Clinical Bottom Line/Effectiveness

Brief Background:

  • Rutin is a yellow crystalline flavonol glycoside (C27H30O16) that occurs in various plants (rue, tobacco, buckwheat, etc.). Upon hydrolysis rutin yields quercetin and rutinose.
  • Quercetin, the flavonoid found in rutin, and rutin are used in many countries as vasoprotectants and are ingredients of numerous multivitamin preparations and herbal remedies (2). The rutosides are naturally occurring flavonoids that have documented effects on capillary permeability and edema (3) and have been used for the treatment of disorders of the venous and microcirculatory systems (4).
  • Oxerutins are standardized mixtures of hydroxyethyl derivatives of rutin, of which tri-7,3',4'-hydroxyethylrutoside (tri-HR or troxerutin, CAS 7085-55-4) is the qualitatively major component (approximately 38%). Several brands of oxerutins (Venoruton®, Paroven®) and rutin derivatives are currently available, and studies have investigated the equivalence of these standardized preparations in clinical trials.
  • There is some evidence for the use of rutin for chronic venous insufficiency, edema, hemorrhoids, microangiopathy, varicosis and venous disorders. Well presented clinical trials are required in these fields before solid recommendations can be made.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.