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Phlorizin

Synonyms/Common Names/Related Substances:

  • Dihydrochalcone glucoside, dihydrochalkone, flavonoids, gamma-PGA-phloridzin conjugates, glucosides, phenolic glucoside, phloretic acid d-glucose, phloretin, phloretin 2'-glucoside, phloretin 2'-O-beta-d-glucoside, phloretin 2'-O-glucose, phloridzin dihydrate, phlorin, phlorizin (1-[2-(beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone), phloroglucinol, phytoestrogens, polyphenols.

Clinical Bottom Line/Effectiveness

Brief Background:

  • Phlorizin, also known as phloridzin, is a flavonoid polyphenol found in several fruit trees, including apple and cherry, and the bark of pear. Phlorizin is considered a major bioactive component in apples (1).
  • Based on a review, phlorizin's principal pharmacological action takes place in the proximal renal tubule and mucosa of the small intestine to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters (2).
  • Phlorizin and its analogs are being investigated for the treatment of diabetes, obesity, and stress hyperglycemia. At this time, clinical studies investigating effects of phlorizin are lacking.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.