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Graviola (Annona muricata)

Synonyms/Common Names/Related Substances:

  • Acetogenins, Annona bonplandiana,Annona cearensis, Annona cherimola,Annona macrocarpa, Annonaceae, annonacin, anona (Tigrigna), anona de broquel (Spanish), anona de puntitas (Spanish), araticum do grande (Portuguese), anona espinhosa (Portuguese), araticu-ponhé (Portuguese), atti (Filipino), Brazilian cherimoya, Brazilian paw paw, cabeza de negro (Spanish), cachiman épineux (French), cachimantier (French), catoche (Spanish), catuche (Spanish), coraçao-de-rainha (Portuguese), coronin, corossel (French), corossol (French), corossol épineux (French), corossolier, curassol (Portuguese), custard apple, durian belanda (Malay), durian benggala (Malay), durian blanda, durian maki (Malay), durian makkah (Malay), goniothalamicin, grand corossol (French), guanaba (Spanish), guanábana (Spanish), guanabana seed, guanábano, Guanabanus muricatus, guanavana, guayabano (Filipino), huanaba (Spanish), isoannonacin, jaca de pobre (Portuguese), jaca do pará (Portuguese), khan thalot (Lao (Sino-Tibetan)), khièp thét (Lao (Sino-Tibetan)), kowól (Creole), llabanos (Filipino), mang câù xiêm (Vietnamese), mstafeli (Swahili), nangka belanda (Javanese), nangka blanda, nangka londa, nangka seberng (Indonesian), pinha azeda (Portuguese), rian-nam (Thai), sappadillo, saua sap (Creole), Sauersack (German), seri kaya belanda (Malayan), sinini, sirsak (Javanese), sorsaka (Dutch), soursap (Dutch), soursop, Stachelannone (German), Stachlinger (German), sweetsop, thu-rian-khack (Thai), thurian-thet (Thai), tiep banla (Cambodian or Khmer), tiep barang (Cambodian or Khmer), toge-banreisi (Japanese), tropical fruit, zapote agrio (Spanish), zapote de viejas (Spanish), zunrzak (Dutch), zuurzak (Dutch).

Clinical Bottom Line/Effectiveness

Brief Background:

  • Graviola, or soursop, is a small, upright evergreen tree that is indigenous to tropical South and North America. The tree produces a large, heart-shaped, edible fruit that is sold commercially.
  • All parts of the graviola tree are used in herbal medicine systems in the tropics, including the fruit, juice, crushed seeds, bark, leaves, and flowers (1;2). Graviola is primarily employed as an alternative treatment for parasitic infections and cancer. It has also been used as a sedative and antispasmodic. Extracts of the leaf, root, stem, and bark of graviola may also be useful for controlling snail species that carry schistosomiasis (3;4;5).
  • In recent times, research has examined the effectiveness of graviola extracts as an insecticidal (6;7), antibiotic, antineoplastic (6;7;8;9;10;11;12;13;14;15;16;17;18;19;20;21;22;23;24;25), antidepressant (26), sedative (27), antifungal (28;29), antimicrobial (12), antiparasitic (30), antiprotozoal (12;31), and antiherpes agent (32;33). However, there are no high-quality human trials supporting the efficacy of graviola for any medical condition. Further research is warranted.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.