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Oculodentodigital syndrome

Related Terms

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Background

  • Oculodentodigital syndrome (ODD) is a form of ectodermal dysplasia that affects the outer layer of a developing baby called the ectoderm. Because the ectodermal layer develops into many parts of the baby's body, including the lens of the eye, parts of the inner ear, fingers, toes, and nerves, these parts may not develop normally. ODD is an inherited genetic condition that usually affects the eyes, teeth, and fingers.
  • ODD is an extremely rare disease. Only 243 cases have been reported, suggesting an incidence of about one in 10 million. Males and females appear to be affected equally.
  • People with ODD tend to have small eyes, a long thin nose, underdeveloped or missing teeth, abnormal hair growth, and finger problems.
  • In addition to small eyes, people with ODD may have abnormally small corneas and may be at higher risk for cataracts, iris atrophy (which includes distortion of the pupil, breakdown of the iris, and holes in the iris), and glaucoma. People with ODD may have hair that is fine, thin, dry, fragile, or in some families, curly. Dental problems associated with ODD include missing or underdeveloped teeth, poor enamel development, and vulnerability to cavities. ODD also affects the hands and feet, most commonly the fourth and fifth fingers. Hand and foot disorders may include camptodactyly, a flexion disorder; syndactyly, fused fingers or toes; and missing phylanges, the small bones that make up the fingers and toes.
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Risk Factors

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Causes

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Signs and Symptoms

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Diagnosis

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Complications

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Treatment

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Integrative Therapies

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Prevention

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.